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KMID : 0882419930450050579
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Korean Journal of Medicine
1993 Volume.45 No. 5 p.579 ~ p.587
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Serum Erythropoietin and Tumor Necrosis Factor alpha in Neoplasms, Chronic Inflammatory Disorders, and Iron Deficiency Anemias
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Abstract
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bjectives : The aim of this study was to determine the serum erythropoietin (S-EPO) level in anemia of chronic disorders (ACD) and the influence of tumor necrosis factor alpha (S-TNE alpha) toS-EPO. We also investigated the relationship between
S-EPO
and S-TNF alpha levels and other factors, such as fever and consumptive syndrome.
Methods : Serum erythropoietin (S-EPO) and tumor necrosis factor alpha (S-TNF alpha)
levels were measured by radioimmunoassay in 35 patients with anemia, classified into three
groups according to their etiology: neoplastic (n=17), chronic inflammatory (n=9), iron
deficiency (n=9), and 10 normal controls.
Results : The iron deficiency anemia group showed a higher mean S-EPO level (mean
vlue±SEM, 229.05±50.50 mU/ml) than the neoplastic (25.09±3.85 mU/ml; p<0.0001), chronic
inflammatory (24.38±4.98 mU/ml; p<0.0001), and normal control groups (11.96±0.99 mU/ml;
p<0.0001).
The neoplastic group showed a higher mean S-TNFalpha level (6.22±0.33 fmol/ml) than
the iron deficiency (3.26±0.18 fmol/ml; p<0.0001) and normal control groups (4.06±
0.12fmol/ml;p<0.0001). The chronic inflammatory disorder group showed a higher mean
S-TNFalpha level (5.39±0.52 fmol/ml) than the iron deficiency anemia group (p<0.0001).
There were no significant differences of S-EPO and s-TNFalpha Level of ACD group in
febrile subjects (9 patients with fever and 17 patients without fever) and in weight loss (10
patients with weight loss and 16 patients without weight loss).
Conclusion : These data suggested that the cause of ACD is thought to be the
inappropriate erythropoiesis and TNFalpha may preferentially inhibits erythropoiesis.
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KEYWORD
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